Clinical benefits of low serum digoxin concentrations in heart failure
نویسندگان
چکیده
منابع مشابه
Clinical benefits of low serum digoxin concentrations in heart failure.
OBJECTIVES We sought to determine whether there was a relationship between serum digoxin concentration (SDC), including SDCs typically regarded as low, and clinical efficacy related to digoxin in patients with symptomatic left ventricular dysfunction. BACKGROUND Digitalis glycosides have been used for 200 years in the treatment of heart failure (HF), but the SDC required for optimal clinical ...
متن کاملDigoxin and reduction in mortality and hospitalization in geriatric heart failure: importance of low doses and low serum concentrations.
BACKGROUND Digoxin reduces hospitalizations due to heart failure (HF) and may also reduce mortality at low serum digoxin concentrations (SDC). Most HF patients are > or = 65 years, yet the effects of digoxin on outcomes in these patients have not been well studied. METHODS Of the 7788 ambulatory chronic HF patients in normal sinus rhythm in the Digitalis Investigation Group trial (1991-1995),...
متن کاملRelationship Between Serum Digoxin Concentrations and Clinical Symptoms of Heart Failure in Pediatric Patients with Heart Disease
The objective of this study was to evaluate relationship between 3 SDC (serum digoxin concentration) subgroups (low, middle and high level) and clinical symptoms of HF (heart failure) in pediatric patients with heart disease. This study was carried out in 175 Thai pediatric patients who were treated with digoxin in routine care. SDCs on steady state were divided into 3 subgroups; low level: <0....
متن کاملCorrelation of serum concentrations with heart concentrations of digoxin in human subjects.
THE UTILITY OF THE ASSAY of serum levels of a drug implies a systematic relationship between this measurement and concentration of the drug at the site of action during "steady state" conditions. Data to support this relationship with respect to digoxin have been sparse, particularly with respect to man. One noteworthy finding is the observation both in animals' and in man2 that digoxin concent...
متن کاملDigoxin in heart failure and cardiac arrhythmias.
HEART FAILURE Digoxin therapy has no effect on mortality in heart failure. Digoxin may be useful for maintaining clinical stability and exercise capacity in patients with symptomatic heart failure. Digoxin appears to be of most benefit in patients with severe heart failure, cardiomegaly and a third heart sound. Digoxin should be used as a second-line drug after diuretics, angiotensin-converting...
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ژورنال
عنوان ژورنال: Journal of the American College of Cardiology
سال: 2002
ISSN: 0735-1097
DOI: 10.1016/s0735-1097(02)01708-4